Drugs and Alzheimer’s

I’m looking at these, uh, new anti Alzheimer’s amyloid drugs, Lecan, aducanumab Umab, these Miracle Wonder Alzheimer’s drugs, do they actually work? I’m reading newspaper articles here in the Telegraph. It says, British patients are flying to New York to obtain, uh, this wonder drug. Another says, we need a Covid style push on dementia drugs, says the ex-head of vaccine task force. I mean, are we talking about mandating drugs here to prevent a disease? Uh, another article here says it slows clinical, uh, the progression of the disease by 60%. Is this true? Let, let’s actually examine the drug company’s own trials. So we’re looking here at the drug, uh, uh, versus placebo. So what happens is there’s a measure of cognitive function. It’s actually based on a questionnaire. And in the placebo group, you can see that there is a steady decrease in cognitive function over a period of 18 months. So what happens in the drug group? Well, again, you can see there is a steady decrease in cognitive function. Uh, it’s a little bit less, I mean a little bit less. In other words, the point is not a single person got better. They all got worse, and those on the drugs got a little bit less worse. Now, let’s actually see what happened in this drug trial. So first of all, this measure, uh, is a questionnaire on cognition. And, uh, what you can see is those in the placebo group got significantly worse over an 18 month period. So what happened to those on the drug? And the answer is they also got significantly worse, but a little bit less worse. Uh, so you know that this 60% is really a, a big exaggeration. It’s just saying that the drug is slightly better than the placebo on a questionnaire in a trial funded by the makers of the drug. Now, how significant is that in the scheme of things? Would anyone notice? Let’s take a look. Comparing with the results that have occurred with some natural nutrients, B vitamins Omega-3, and remember, your brain is actually built out of Omega-3, and the B vitamins are so important because they help to bind the Omega-3 into the brain. So let’s start with the drugs. We, we have aducanumab. It produced a statistically significant effect. The Food and Drug Administration have 10 experts. They were asked to vote whether it should get a license. Nine of the experts said no. Uh, one abstained and it got a license. Three resigned immediately. The next drug kinumab was a little bit better, uh, statistically, and the third umab a little bit better still. But the really important point is that none of these drugs actually produced a clinically significant effect, statistically significant. Just remember, these are trials funded by the makers of the drug, but clinically significant. No, not at the level where the person, the carer, the partner, the doctor would actually notice. Now, in a very good study at the University of Oxford, which gave B vitamins, and these are homocysteine lowering B vitamins B six, folate B12, they got a highly clinically significant effect. So much so that 30% of the people in the trial ended the year with a clinical dementia rating. That’s what’s being measured here of zero. In other words, 30% would no longer be diagnosable with dementia. And then a few years ago, we discovered that the B vitamins need Omega-3 to work. And in a study giving Omega-3 with sufficient B vitamin status, there was an even greater effect. I mean, we’re talking three times bigger than any of these drugs. There’s a lot of articles now in the science papers saying it’s unethical to continue to give these anti amyloid injections. Do they work? Yeah, they, they do. The idea is that there’s amyloid plaque in your brain, and if you inject the antiamyloid, uh, uh, drug, it will reduce the plaque, which it does, but it’s not producing a clinically significant effect. The next thing we have to look at is, well, what about the adverse effects? I mean, there are no adverse effects from the B vitamins, the omega threes. There are only benefits. Uh, but in the Lecan trial, uh, there were three associated deaths. The third got brain bleeding or swelling. In the UMAB trial, there were four associated deaths. 20% got brain bleeding, 24% got swelling. So these are injections given every two weeks or four weeks. And what we now understand is because of this significant, I mean literally one third of people getting adverse effects with every injection, you need a brain scan to check. There isn’t brain bleeding and swelling and some people will die. And this is what we are calling a breakthrough. Now, really the hard measure of of the disease is brain shrinkage. That’s what dementia is. Brain shrinkage and Alzheimer’s. It’s brain shrinkage. And so much so that a, a diagnosis of Alzheimer’s can only be made by doing a brain scan to see if there is a significant level of brain shrinkage. So let’s take a look at what happens in that actual hard indisputable fact of brain shrinkage. So in the study with bi vitamins, uh, there was a more than 50% decreased rate of brain shrinkage versus placebo. And in those with sufficient Omega-3, also given the B vitamins, there is a 73% reduced rate of brain shrinkage. And by the way, that that reduced the brain shrinkage to the level that you find in normal, healthy, older people who have no cognitive decline. So in other words, that hallmark of the disease brain shrinkage, accelerated brain shrinkage was eliminated with Omega-3 and B vitamin. So simple, so cheap, so safe. So what happened with, with, with these anti amyloid drugs? Well, the latest umab reported in its own study, even though this didn’t hit the newspapers, that the drug increased the rate of brain shrinkage, uh, uh, by about 20%. So really, you know, that’s your choice. And, uh, in this article in the Guardian, uh, a professor, uh, from University College London, uh, made this statement said, my own view is that these drugs can’t possibly be cost effect. The benefit of treatment is so tiny and the cost of giving them and ensuring patient safety will be so high, and we’re talking about a hundred thousand dollars a year. Plus the cost of brain scans plus the risks Andy added. Nobody has explained the worrying accelerated brain volume loss seen with these drugs. So that’s really what we’ve got in terms of the science. Highly ineffective drugs with a very, very high rate of adverse effects, which include death and brain. So my very strong advice to you is to take your own health and your own brain health in your own hands. Go to food for the brain.org. It’s not for profit. Complete an accurate validated cognitive function test. Find it exactly where you’re at, which is followed by a questionnaire which identifies your risk areas. Perhaps the brain fats Omega-3, perhaps the B vitamins, but there are others like sugar, lack of exercise, stress, sleep, and so on. Fill in the questionnaire, find out what’s driving your risk, and the the odds are that you are gonna get a much greater protective effect with no adverse risks at all. This disease is not a consequence of a lack of drugs, and it is not going to be solved by drugs. It’s a consequence of how we live. What we eat are diet and lifestyle. You and only you are the architect of your own brain’s future destiny.